Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation

Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation.

The marrow of a dog affected with cyclic neutropenia (CN) was transplanted into an unaffected supralethally irradiated litermate. Prompt engraftment occurred, and cyclic rises and falls in numbers of platelets, reticulocytes, and granulocytes were noted in the recipient soon after engraftment. Prior to transplantation and under hypoxic conditions, the donor had serum erythropoietin (ESF) peak l...

Autoimmune neutropenia after bone marrow transplantation.

Shastri and Logue, in their otherwise thorough review' of the laboratory and clinical aspects of autoimmune neutropenia, fail to mention the association between autoimmune neutropenia and bone marrow transplantation. Approximately 25 such cases have now been reported,'-" and a recent prospective study from Johns Hopkins" suggests that more than half the cases of otherwise unexplained posttransp...

Autoimmune thrombocytopenia and neutropenia after bone marrow transplantation.

Impaired erythropoietin response to anemia after bone marrow transplantation.

Delayed erythroid recovery is common after bone marrow transplantation (BMT), with some patients continuing to require red blood cell (RBC) transfusion support for as long as 1 year. While the etiology is multifactorial, inadequate stimulation of erythroid progenitors by the erythroid growth factor, erythropoietin, may play a role. In this study, the erythropoietin response to anemia of 70 cons...

Cytomegalovirus infection causes delayed platelet recovery after bone marrow transplantation.

The pathogenic effect of cytomegalovirus (CMV) infection on the hematopoietic recovery after bone marrow transplantation (BMT) was retrospectively studied in 87 recipients of (nonpurged) autologous BMT and in 56 recipients of allogeneic BMT from HLA-identical siblings. Indications for autologous BMT were lymphomas or acute leukemias and for allogeneic BMT various malignancies or aplastic anemia...